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Laboratory Animal Resource Bank,National Institutes of Biomedical Innovation, Health and Nutrition HOME > mice > Ace2-KO mice Strain Detail: Ace2-KO mice Strain information Resource No. nbio388 Strain name Ace2-KO Strain Nomenclature Common name/Synonyms Strain types mutant Background strain C57BL/6N Institution Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition Developer Osamu Suzuki Depositor Osamu Suzuki Conditions of distribution Collaboration with the depositor only. It's necessary to obtain depositor's consent on use of biological resources. contact us Animal Health Report Strain description Knockout mice of Angiotensin-converting enzyme 2 (Ace2). An entire coding sequence of the Ace2 gene on X chromosome in 57BL/6N mice was removed by CRISPR/Cas9 system using TAKE method with Cas9 proteins and two guide RNAs targeting 5’- and 3’-UTRs of the gene. These mice are useful for studies of hypertension and new coronaviruses. For example, it is possible to cross human Ace2-Tg mice (Ace2-Tg#5，Ace2-Tg#16，Ace2-Tg#17) with the Ace2-KO mice to produce mice whose Ace2 molecules are humans only. Reference(s) Resource information Cryopreserved sperm In-house Genotype Medium From other institutions Genotype Medium Cryopreserved embryo In-house Mating System Genotype Medium From other institutions Mating System Genotype Method Strain status / Availability Cryopreserved sperm Cryopreserved embryo Live animals Gene information Mutation types Knockout Gene symbol Ace2 Gene name Angiotensin-converting enzyme 2 Genotyping information Genotyping protocol for Ace2-KO mice (pdf). To Japanese Animal Resource Bank Supplies of mice Safe deposits Deposits of mice Price list List of mice Available mice By diseases By affected organs Microbiological monitoring Animal room conditions Research Research Recent papers Site info Site map Contact Copyright(c) Laboratory Animal Resource Bank at NIBIOHN, Japan ([email protected]). All Rights Reserved. Last update: $Date:: 2022-03-03 14:29:06 +09#$